Fig. 1

Flow of statistical information in the Staphylococcus aureus Network Adaptive Platform trial. This hypothetical realisation is at its third scheduled analysis, having previously satisfied a decision rule at the second scheduled analysis leading to analyses to support a domain-specific conclusion

Note: the flow of information also approximates the chronological order that the documents are produced. SAP, statistical analysis plan; SIG, statistical implementation guide; DSMC, data safety and monitoring committee. * Simulation report may be updated upon trial adaptation. † Additional domain-specific appendices may be added where required. Documents produced solely by the blinded team are unshaded, documents solely produced by the unblinded analytic team are shaded grey