Table 1 Prior distributions of outcome parameters
Priors | Mean (log RR) | SD (log RR) | Rationale | |
|---|---|---|---|---|
Mortality | Uninformative | 0 | 3 | Let data exert maximum influence |
Skeptical | 0 | 0.11 | Assuming 38% mortality in the control group based on interim analysis and a 10% probability of an MCID (> 5% reduction ARD) | |
Informative | NA | NA | NA | |
Thrombotic complications | Uninformative | 0 | 3 | Let data exert maximum influence |
Skeptical | 0 | 0.69 | Assuming 17% thrombotic complications in the control group based on interim analysis and a 10% probability of an MCID (> 10% reduction ARD) | |
Informative | NA | NA | NA | |
Hemorrhagic complications | Uninformative | 0 | 3 | Let data exert maximum influence |
Skeptical | 0 | 0.14 | Assuming 60% hemorrhagic complications in the control group based on interim analysis and a 10% probability of an MCID (> 10% reduction ARD) | |
Informative | NA | NA | NA |